The aim of the present work was to develop and optimize liquid Self nanoemulsifying drug delivery system SNEDDS (SNEDDS) formulation for improvement of solubility and dissolution of Isradipine (ISP). A 3- factor, 3- level Box Behnken design (BBD) was used to optimize the independent variables such as amount of Capmul MCM: Captex 200, 1:2 (X1), Tween 80 (X2), PEG 400 (X3) in order to obtain a formulation which emulsify rapidly, gives rapid drug release and also have droplet size as small as possible. The dependent variables selected were emulsification time (Y1), % transmission (Y2), % drug release after 15 minutes (Y3), and droplet size (Y4). Following optimization, the values of independent variables (X1, X2, and X3) were 54, 198, and 149 mg, respectively for maximizing (Y2 and Y3) and minimizing (Y1 and Y4). The optimized formulation of ISP showed a significant increase in dissolution rate (which gives almost 100 % drug release within 10 minutes) compared to the plain ISP under the same conditions. In conclusion BBD may be use for the optimization of liquid SNEDDS of ISP and this optimize formulation could be promising to improve solubility and dissolution of ISP.
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